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If an alien spacecraft landed in Dr. Avi Loeb’s backyard tomorrow, he would readily step on, leave his family behind and take off to discover the great beyond.

Obviously, he’d be giving up a lot, but it’s for an essential cause, he says: Humans need to explore the possibilities for human life beyond earth.

“We know the sun will burn up the surface of the earth within a billion years,” he says. “We won’t be able to stay here.”

Loeb, an Israeli-American astrophysicist at Harvard University, shared these thoughts recently in a podcast conversation with Dr. Tal Patalon, head of Kahn Sagol Maccabi,...